Teodoro Sampaio is a municipality in the state of São Paulo in Brazil. The population is 23,273 (2020 est.) in an area of 1556 km². The elevation is 321 m. The municipality contains part of the 246,800 hectares (610,000 acres) Great Pontal Reserve, created in 1942. It contains the 33,845 hectares (83,630 acres) Morro do Diabo State Park, created in 1986. It also contains 36% of the 6,677 hectares (16,500 acres) Mico Leão Preto Ecological Station, established in 2002.