Mathangwane is a village in Botswana's Central District, administered under the Tutume Sub-district Council. Situated approximately 25 kilometres west of Francistown along the A3 highway, the village lies at the confluence of the Shashe and Vukwi rivers. It is predominantly located on the left bank of the Shashe River. According to the 2011 Population and Housing Census, Mathangwane had a population of 5,075. The village is distinguished by its numerous river valleys, primarily formed by tributaries of the Shashe River. These valleys traditionally serve as natural boundaries for the village's community wards, locally referred to as dikgotlana.