Groß Pankow (Prignitz) is a municipality in Prignitz district, Brandenburg, Germany. The municipality was formed in 2001 from the union of municipalities of the former Amt of Groß Pankow/Prignitz and some in Amt Pritzwalk-Land. Amt Groß Pankow/Prignitz was then dissolved. From 1815 to 1945, the constituent localities of Groß Pankow were part of the Prussian Province of Brandenburg. From 1952 to 1990, they were part of the Bezirk Potsdam of East Germany. Groß Pankow is connected via German Federal Highway B 189 to the cities of Pritzwalk, Perleberg, Wittenberge and Magdeburg.